Cisplatin, a cytotoxic agent used in treating cancer, at high doses induces hepatotoxicity. The present study was undertaken to examine the antioxidant potential of Moringa oleifera L (MO) seed oil against the toxicity of Cisplatin in albino rats.. In literature seed extract of Moringa species reported to have anti-inflammatory, purgative, tonic, and analgesic, potential antitumor, anti-fungal, antispasmodic, anti-inflammatory and diuretic activity. In view of this, the present study investigates the protective effect of Moringa oleifera oil on Cisplatin (CP) induced damage to liver. A dose- dependent increases in biochemical parameters, such as SGOT, SGPT, ALP and a decrease non-enzyme antioxidants and lipid peroxidase levels level. Serum/urine parameters, enzymes of carbohydrate metabolism and oxidative stress were analyzed. Cisplatin caused perturbation of the antioxidant defence as is reflected by the decrease in the activities of Catalase, superoxide dismutase and glutathione peroxidase. However, these alterations were ameliorated in Cisplatin treated rats fed on Moringa oil. Present results show that Moringa oil to Cisplatin treated rats ameliorated Cisplatin-induced hepatotoxicity and other deleterious effects due to its intrinsic biochemical/antioxidant properties.
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